Get health care assist at once in case you see any of the next: sluggish/shallow respiratory, severe drowsiness/trouble waking up, confusion.
The Promethazine VC with Codeine manufacturer identify has long been discontinued during the U.S. If generic versions of the item happen to be authorised by the FDA, there might be generic equivalents offered.
Codeine makes peripheral vasodilation which may bring about orthostatic hypotension or syncope. Manifestations of histamine release and/or peripheral vasodilation may involve pruritus, flushing, crimson eyes and sweating and/or orthostatic hypotension.
This medicine controls nausea and vomiting. For that reason, it might protect up a lot of the indications of overdose because of other medicines or perhaps the signs and symptoms of encephalopathy or Reye's syndrome.
Antihistamines and codeine are both contraindicated to be used within the procedure of reduced respiratory tract signs, which includes bronchial asthma.
Avoid the usage of Promethazine with Codeine Oral Alternative in individuals with head injuries, intracranial lesions, or perhaps a pre-current increase in intracranial tension. In sufferers who can be at risk of the intracranial results of CO2 retention (e.
Evaluate Every affected person's threat before prescribing Promethazine with Codeine Oral Answer, prescribe Promethazine with Codeine Oral Remedy to the shortest duration that's constant with person affected person therapy goals, monitor all people frequently for the event of addition or abuse, and refill only immediately after reevaluation of the need for ongoing cure. [see Warnings and Safeguards (5.one)]
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Epinephrine – Due to the prospective for promethazine to reverse epinephrine's vasopressor impact, epinephrine really should not be employed to take care of hypotension affiliated with promethazine overdose.
Codeine has good antitussive action, Even though less than that of morphine at equivalent doses. It's Utilized in desire to morphine, since side effects are rare at the standard antitussive dose of codeine.
Symptoms and symptoms of overdosage with promethazine vary from delicate despair from the central nervous process and cardiovascular system to profound hypotension, respiratory depression, unconsciousness and sudden Loss of life.
Make use of other supportive steps (which include oxygen and vasopressors) from the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Highly developed lifestyle-assist procedures. Gastric emptying might be beneficial in taking away unabsorbed drug.
Hemodialysis is not really routinely made use of to improve the elimination of codeine or promethazine from the human body.
4)]. Observational scientific studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the danger of drug-associated mortality compared to usage of opioids by itself. As a consequence of very similar pharmacologic Houses, it truly is realistic to be expecting equivalent threat with concomitant use of opioid cough remedies and benzodiazepines, other CNS depressants, or Alcoholic beverages.